Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear.
Results: Comparative analysis between lymphoid rich and stromal areas demonstrated a strong association between CXCL13, CCL21 and CCL19 with synovial lymphoid tissue (p<), not recognised for CXCL12 (p= ). Within progressive stages of aggregate formation CXCL13, CCL21 and CCL19 demonstrated a higher prevalence in larger aggregates (grade 23), while CXCL12 induction was not .
Lymphoid tissue. Acquisition and processing of lymphoid tissue were approved by the local ethical committee. Human tonsils from otherwise healthy ... Human lymphocyte aggregate cultures (HLAC) were prepared by transferring minced tissue and tissue fragments into a cell strainer (70 M;
Jun 20, 2014· can exist as simple lymphoid aggregates or as more sophis ticated structures that histologically resemble secondary lymphoid organs (SLOs)7,8 (TABLE 1). The spatial organization of leukocytes into defined, compartmentalized B cellrich and .
Malignant lymphoid aggregates are clonal proliferations of B cells. 8,10–12 As such, they will be amenable to detection Accepted for publication September 16, 1999.
Human immunodeficiency virus, life cycle, diagram. Human immunodeficiency virus within lymphoid tissues, diagram. Human immunodeficiency virus, process of infection, diagram. Human immunodeficiency virus, schematic diagram of genome. Human immunodeficiency virus (HIV) subtypes and simian immunodeficiency virus (SIV) phylogeny, diagram.
lymphoid follicles can develop out of any lymphoid aggregate. Importantly, only the microanatomic organisation of a lymphoid follicle, with the ability of germinal centre develop
Aim: To investigate the development of lymphoid aggregates in the conjunctiva after corneal transplantation in rats. Methods: LEW or PVG strain corneas were transplanted orthotopically to PVG rats. Cornea and conjunctiva were examined clinically for up to 42 days. Eyes were removed with attached conjunctiva on days 10 and 15 after transplantation (before and during rejection), together .
Tertiary lymphoid tissue is a term describing ectopic lymphoid aggregates that accumulate during the process of chronic immune stimulation. Tertiary lymphoid organs exhibit characteristics usually associated with the secondary lymphoid organs (lymph nodes, Peyer's patches, and the spleen).
Reactive lymphoid hyperplasia is the prototype of a cytologic polymorphous lymphoid cell pattern commonly associated with a benign, reactive and reversible lymphadenopathy. Bacteria, viruses, chemicals, and iatrogenic drugs are identified in approximately 10% of cases. The etiology remains unknown in most cases.
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Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course of autoimmune, infectious, and chronic graft rejection diseases, in which a sustained lymphocyte activation occurs in the presence of ...
Oral Lymphoepithelial Cyst: A Case Report . Neerja Sethi, Sangeeta R Patankar . Abstract . The lymphoepithelial cyst is an uncommon lesion in the mouth. It develops within a benign lymphoid aggregate or accessory tonsil of the oral or pharyngeal mucosa. The usual presentation is of a round or oval swelling of the oral mucosa of normal color.
Innate lymphoid cells (ILCs) represent a relatively small group of cells that are the innate counterpart of adaptive T cells and are particularly enriched at mucosal and barrier sites, but are also found in secondary lymphoid organs and circulation (Artis Spits, 2015).
In this study, we provide the first indepth demonstration that the development of inflammatory infiltrates within pancreatic islets of NOD mice is a highly organized process leading to the progressive acquisition of features of SLOs and the formation of functional lymphoid aggregates.
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